|
KMID : 0363320060270010114
|
|
Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 1 p.114 ~ p.125
|
|
|
Effect of Scutellaria Radix extract drug on immune cells and cytokines in BALF of OVA-induced asthmatic mice
|
|
Cho Cheol-Jun
Lim Do-Hee
Hwang Ji-Ho
Yang Soo-Young
Park Yang-Chun
|
|
|
Abstract
|
|
|
objective : The purpose of this research is to examine the effects of Scutellaria Radix(SR) extract on immune cells and cytokines in ovalbumin(OVA)-induced asthmatic mice.
Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 9 weeks. In this experiment, one group was not treated, and the other group was treated with SR extract for six weeks(five times per week) and analyzed by ELISA and flow cytometer.
Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-13 in BALF (bronchoalveolar lavage fluid) compared with that of control group. However,IFN{gamma} in the SR group increased significantly compared with that of control group. Additionally, the population of CD3e -/CCR3 +,;CD69 +/CD3e +,;IgE +/B220 +,;CD11b +/Gr-1 + cells in the SR group decreased compared with that of control group.
conclusion : The results of this study support a role for SR as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing IFN{gamma}, Which helps prevent such reactions.
|
|
|
KEYWORD
|
|
|
Scutellaria Radix, asthma, cytokine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|